Fig. 6: Lung cancer cells stimulate the activation of the STAT3 signaling pathway in microglia to promote the expression of SCD1. | Cell Death & Disease

Fig. 6: Lung cancer cells stimulate the activation of the STAT3 signaling pathway in microglia to promote the expression of SCD1.

From: Lung cancer cells upregulate stearoyl-CoA desaturase 1 in microglia by activating the STAT3 pathway to change microglial inflammatory response in lung-to-brain metastases

Fig. 6

A Heatmap showing significant phosphorylated protein differences between the CAY10566-treated group and the untreated group in microglia pretreated with A549-BrM medium. B Phospho-proteins of the JAK-STAT3 signaling pathway in the phospho-antibody array. C Representative western blot images showing the expression of pSTAT3 and STAT3 in microglia co-cultured with lung cancer cells or control, and the histogram showing the quantitative array of the ratio of pSTAT3 to STAT3 (n = 4). D Western blot results showing the expression of SCD1, STAT3, and pSTAT3 in microglia cultured in the presence of different concentrations of CAY10566 (n = 4). E Correlation analysis showing a positive correlation between the expression of SCD1 and pSTAT3/STAT3. F Western blot results showing the expression of SCD1, STAT3, and pSTAT3 in microglia cultured in the presence of different concentrations of Stattic (n = 4). (*P < 0.05).

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