Fig. 2: PARL deficiency exacerbates MPTP-induced motor and cognitive deficits in PD mice models. | Cell Death & Disease

Fig. 2: PARL deficiency exacerbates MPTP-induced motor and cognitive deficits in PD mice models.

From: PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson’s disease

Fig. 2

A, D, E Open-field behavior test analysis: Total Track route, Distance and Total Central square time ratio. B, F Elevated Plus Maze: Test the Total Track route and Mean latency to enter the open arms of the elevated plus maze in a 5-min test period. C, G Morris water maze test: representative swimming tracks of mice (time to find the platform) in Morris water maze test. The number of entries in the platform was significantly increased in shPARL mice compared to Sham mice on the last day. H At the same time, the escape latency was significantly decreased in shPARL mice compared to Sham mice. I Latency to fall of various groups assessed by the rotarod test. (ns not significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, one-way ANOVA followed by Turkey’s test for multiple comparisons, n = 6 per group. Bars represent mean ± SD).

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