Table 1 Statistical analysis of proteins identified mass spectrometry analysis of MID1 immunoprecipitates

From: Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis

Protein name

Gene ID

Log2 ratio

P-value

ATP-binding cassette sub-family D member 3

ABCD3

2.75E+01

2.04E-03

ATP-binding cassette sub-family F member 2

ABCF2

2.88E+01

5.96E-04

Apoptotic chromatin condensation inducer in the nucleus

ACIN1

2.72E+01

1.39E-02

Aldehyde dehydrogenase X, mitochondrial

ALDH1B1

2.62E+01

3.61E-04

Mitochondrial 10-formyltetrahydrofolate dehydrogenase

ALDH1L2

2.66E+01

1.97E-02

THO complex subunit 4

ALYREF

2.99E+01

7.55E-04

Serine/threonine-protein phosphatase 6 reg. ankyrin repeat subunit A

ANKRD28

2.63E+01

1.85E-02

Coatomer subunit delta

ARCN1

2.65E+01

2.36E-02

Activating signal cointegrator 1 complex subunit 3

ASCC3

2.59E+01

7.96E-03

ATPase family AAA domain-containing protein 3A

ATAD3A

1.77E+00

3.98E-02

Sodium/potassium-transporting ATPase subunit alpha-1

ATP1A1

2.72E+01

4.39E-04

Ribosome biogenesis protein BMS1 homolog

BMS1

2.90E+01

8.92E-03

Ribosome biogenesis protein BRX1 homolog

BRIX1

2.68E+01

1.41E-02

Caprin-1

CAPRIN1

2.80E+01

5.88E-03

Coiled-coil domain-containing protein 124

CCDC124

2.94E+01

1.91E-04

T-complex protein 1 subunit gamma

CCT3

2.63E+01

4.86E-02

T-complex protein 1 subunit epsilon

CCT5

2.64E+01

1.42E-03

Cell division cycle 5-like protein

CDC5L

3.04E+01

3.51E-03

Centrosomal protein of 170 kDa

CEP170

2.71E+01

2.53E-03

Chromatin target of PRMT1 protein

CHTOP

2.81E+01

3.45E-02

CLIP-associating protein 2

CLASP2

2.74E+01

4.83E-03

Methylosome subunit pICln

CLNS1A

2.97E+01

2.16E-03

Coatomer subunit gamma-2

COPG2

2.59E+01

2.98E-04

Coronin-1C

CORO1C

3.03E+01

2.00E-02

Cleavage and polyadenylation specificity factor subunit 6

CPSF6

2.93E+01

4.13E-03

Cleavage and polyadenylation specificity factor subunit 7

CPSF7

2.73E+01

2.20E-03

Probable ATP-dependent RNA helicase DDX17

DDX17

3.22E+01

1.28E-02

Probable ATP-dependent RNA helicase DDX20

DDX20

2.73E+01

2.81E-02

Nucleolar RNA helicase 2

DDX21

3.01E+01

8.42E-03

Probable ATP-dependent RNA helicase DDX23

DDX23

2.93E+01

4.58E-03

ATP-dependent RNA helicase DDX3X

DDX3X

2.66E+01

5.42E-04

Probable ATP-dependent RNA helicase DDX41

DDX41

2.73E+01

4.88E-03

Probable ATP-dependent RNA helicase DDX5

DDX5

2.97E+01

1.38E-02

ATP-dependent RNA helicase DDX50

DDX50

2.65E+01

5.75E-03

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

DHX15

2.76E+01

6.67E-03

Putative ATP-dependent RNA helicase DHX30

DHX30

2.99E+01

1.03E-02

ATP-dependent RNA helicase A

DHX9

7.63E+00

4.50E-03

Elongation factor 2

EEF2

4.68E+00

8.14E-03

116 kDa U5 small nuclear ribonucleoprotein component

EFTUD2

3.04E+01

6.54E-03

Eukaryotic translation initiation factor 3 subunit A

EIF3A

3.34E+01

2.89E-04

Eukaryotic translation initiation factor 3 subunit B

EIF3B

3.19E+01

6.22E-03

Eukaryotic translation initiation factor 3 subunit C

EIF3C

3.23E+01

1.43E-03

Eukaryotic translation initiation factor 3 subunit D

EIF3D

3.01E+01

1.72E-03

Eukaryotic translation initiation factor 3 subunit E

EIF3E

3.15E+01

2.60E-03

Eukaryotic translation initiation factor 3 subunit F

EIF3F

3.08E+01

9.00E-03

Eukaryotic translation initiation factor 3 subunit G

EIF3G

2.99E+01

1.64E-04

Eukaryotic translation initiation factor 3 subunit I

EIF3I

3.07E+01

4.95E-03

Eukaryotic translation initiation factor 3 subunit J

EIF3J

2.75E+01

2.97E-04

Eukaryotic translation initiation factor 3 subunit K

EIF3K

2.75E+01

4.35E-02

Eukaryotic translation initiation factor 3 subunit L

EIF3L

3.20E+01

1.62E-03

Eukaryotic translation initiation factor 3 subunit M

EIF3M

3.06E+01

2.52E-02

Eukaryotic translation initiation factor 3 subunit H

EIF3S3

2.98E+01

4.34E-03

Eukaryotic initiation factor 4A-I

EIF4A1

2.82E+01

1.28E-02

Eukaryotic initiation factor 4A-III

EIF4A3

2.66E+01

2.37E-02

Eukaryotic translation initiation factor 4B

EIF4B

3.07E+01

1.05E-02

Eukaryotic translation initiation factor 6

EIF6

2.71E+01

1.74E-02

Emerin

EMD

2.73E+01

1.99E-02

Erlin-2

ERLIN2

2.81E+01

7.54E-03

Exosome component 10

EXOSC10

2.76E+01

3.45E-03

Exosome complex component RRP45

EXOSC9

2.59E+01

2.53E-02

Constitutive coactivator of PPAR-gamma-like protein 1

FAM120A

2.74E+01

1.36E-02

Phenylalanine--tRNA ligase alpha subunit

FARSA

2.78E+01

7.54E-03

Phenylalanine--tRNA ligase beta subunit

FARSB

2.78E+01

1.17E-02

40S ribosomal protein S30

FAU

2.85E+01

2.31E-03

Protein furry homolog-like

FRYL

3.02E+01

2.54E-02

Gem-associated protein 4

GEMIN4

2.71E+01

2.53E-03

Guanine nucleotide-binding protein subunit beta-2-like 1

GNB2L1

3.25E+01

3.47E-04

Nucleolar GTP-binding protein 2

GNL2

2.75E+01

7.11E-03

Guanine nucleotide-binding protein-like 3

GNL3

2.69E+01

4.03E-04

Golgin subfamily A member 3

GOLGA3

2.93E+01

3.96E-03

General transcription factor 3C polypeptide 2

GTF3C2

2.75E+01

3.97E-03

General transcription factor 3C polypeptide 3

GTF3C3

2.57E+01

3.56E-02

General transcription factor 3C polypeptide 4

GTF3C4

2.70E+01

2.46E-03

Nucleolar GTP-binding protein 1

GTPBP4

2.87E+01

1.26E-02

Histone H2B

HIST1H2BN

2.99E+01

1.62E-02

Heterogeneous nuclear ribonucleoproteins C1/C2

HNRNPC

3.08E+01

3.22E-04

Heterogeneous nuclear ribonucleoprotein D0

HNRNPD

2.60E+01

2.60E-02

Heterogeneous nuclear ribonucleoprotein F

HNRNPF

2.74E+01

4.67E-03

Heterogeneous nuclear ribonucleoprotein K

HNRNPK

2.96E+01

9.43E-04

Heterogeneous nuclear ribonucleoprotein M

HNRNPM

6.56E+00

1.98E-02

Heterogeneous nuclear ribonucleoprotein R

HNRNPR

2.99E+01

4.29E-03

Heterogeneous nuclear ribonucleoprotein U

HNRNPU

3.23E+01

2.34E-03

Isoleucine--tRNA ligase, cytoplasmic

IARS

2.72E+01

3.12E-03

Insulin-like growth factor 2 mRNA-binding protein 1

IGF2BP1

3.18E+01

1.09E-03

Insulin-like growth factor 2 mRNA-binding protein 3

IGF2BP3

2.81E+01

1.22E-02

Interleukin enhancer-binding factor 2

ILF2

3.10E+01

1.08E-02

Interleukin enhancer-binding factor 3

ILF3

3.27E+01

2.99E-03

Importin-8

IPO8

2.74E+01

1.30E-02

Insulin receptor substrate 4

IRS4

1.33E+00

3.38E-03

Influenza virus NS1A-binding protein

IVNS1ABP

3.33E+01

3.05E-03

Tyrosine-protein kinase JAK1

JAK1

2.88E+01

4.64E-03

BTB/POZ domain-containing protein KCTD17

KCTD17

2.96E+01

1.23E-02

BTB/POZ domain-containing protein KCTD5

KCTD5

2.96E+01

3.67E-04

Kinesin-like protein KIF11

KIF11

1.48E+00

1.25E-03

La-related protein 1

LARP1

3.17E+01

9.37E-04

La-related protein 4

LARP4

2.86E+01

7.22E-03

La-related protein 4B

LARP4B

2.65E+01

8.21E-03

LIM domain and actin-binding protein 1

LIMA1

2.98E+01

7.34E-03

Leucine-rich PPR motif-containing protein, mitochondrial

LRPPRC

2.63E+01

8.82E-03

Putative RNA-binding protein Luc7-like 2

LUC7L2

3.00E+01

3.39E-03

Luc7-like protein 3

LUC7L3

2.81E+01

5.20E-03

Microtubule-associated protein 1B

MAP1B

3.01E+01

3.76E-03

Serine/threonine-protein kinase MARK2

MARK2

2.60E+01

3.76E-03

Methionine--tRNA ligase, cytoplasmic

MARS

2.62E+01

1.62E-03

Matrin-3

MATR3

2.87E+01

1.32E-03

DNA replication licensing factor MCM7

MCM7

2.83E+01

8.19E-03

E3 ubiquitin-protein ligase Midline-1

MID1

3.76E+01

3.26E-04

Putative helicase MOV-10

MOV10

2.77E+01

2.49E-02

28S ribosomal protein S17, mitochondrial

MRPS17

2.91E+01

6.96E-03

28S ribosomal protein S22, mitochondrial

MRPS22

2.74E+01

4.69E-03

28S ribosomal protein S25, mitochondrial

MRPS25

2.71E+01

1.14E-02

28S ribosomal protein S27, mitochondrial

MRPS27

2.64E+01

3.48E-02

Protein LYRIC

MTDH

2.72E+01

1.03E-02

Myb-binding protein 1A

MYBBP1A

2.90E+01

1.44E-04

Myosin-10

MYH10

1.13E+00

2.28E-02

Myosin-9

MYH9

2.92E+01

4.78E-03

Unconventional myosin-Ib

MYO1B

2.71E+01

2.88E-02

Nicotinamide phosphoribosyltransferase

NAMPT

2.75E+01

8.55E-03

Nucleosome assembly protein 1-like 1

NAP1L1

2.57E+01

7.18E-03

Nuclear cap-binding protein subunit 1

NCBP1

2.81E+01

4.89E-04

Nucleolin

NCL

2.86E+01

6.74E-03

Nucleolar complex protein 4 homolog

NOC4L

2.80E+01

8.27E-03

Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

NOP2

2.62E+01

5.08E-03

Cleavage and polyadenylation specificity factor subunit 5

NUDT21

2.96E+01

6.21E-04

OTU domain-containing protein 4

OTUD4

2.74E+01

1.45E-03

Prolyl 4-hydroxylase subunit alpha-1

P4HA1

2.79E+01

4.44E-03

Proliferation-associated protein 2G4

PA2G4

3.08E+01

7.55E-03

Polyadenylate-binding protein 1

PABPC1

3.23E+01

2.17E-03

Polyadenylate-binding protein 4

PABPC4

3.22E+01

2.78E-03

Programmed cell death protein 4

PDCD4

2.94E+01

8.37E-03

Proline-, glutamic acid- and leucine-rich protein 1

PELP1

2.66E+01

9.09E-03

Serine/threonine-protein phosphatase PGAM5, mitochondrial

PGAM5

2.86E+01

3.52E-03

Protein arginine N-methyltransferase 5

PRMT5

3.54E+01

6.16E-04

Pre-mRNA-processing factor 19

PRPF19

3.02E+01

3.67E-03

U4/U6 small nuclear ribonucleoprotein Prp3

PRPF3

2.70E+01

1.69E-02

U4/U6 small nuclear ribonucleoprotein Prp31

PRPF31

2.97E+01

8.19E-04

U4/U6 small nuclear ribonucleoprotein Prp4

PRPF4

2.64E+01

3.83E-03

Pre-mRNA-processing factor 6

PRPF6

2.98E+01

6.12E-03

Pre-mRNA-processing-splicing factor 8

PRPF8

3.11E+01

3.06E-03

Ribose-phosphate pyrophosphokinase 1

PRPS1

5.58E+00

3.60E-03

Ribose-phosphate pyrophosphokinase 2

PRPS2

2.93E+01

1.56E-02

Phosphoribosyl pyrophosphate synthase-associated protein 1

PRPSAP1

3.05E+01

8.50E-03

Phosphoribosyl pyrophosphate synthase-associated protein 2

PRPSAP2

3.25E+01

2.15E-04

Protein PRRC2A

PRRC2A

2.85E+01

8.43E-03

Protein PRRC2C

PRRC2C

2.97E+01

2.05E-02

26S protease regulatory subunit 4

PSMC1

2.97E+01

5.78E-03

26S protease regulatory subunit 7

PSMC2

3.07E+01

8.06E-04

26S protease regulatory subunit 6A

PSMC3

2.89E+01

5.50E-03

26S protease regulatory subunit 6B

PSMC4

1.19E+00

1.54E-02

26S protease regulatory subunit 8

PSMC5

4.55E+00

3.71E-04

26S protease regulatory subunit 10B

PSMC6

2.84E+01

1.52E-03

26S proteasome non-ATPase regulatory subunit 1

PSMD1

2.97E+01

2.12E-03

26S proteasome non-ATPase regulatory subunit 10

PSMD10

2.85E+01

2.02E-02

26S proteasome non-ATPase regulatory subunit 11

PSMD11

3.02E+01

1.94E-02

26S proteasome non-ATPase regulatory subunit 12

PSMD12

2.90E+01

4.18E-03

26S proteasome non-ATPase regulatory subunit 13

PSMD13

2.95E+01

3.11E-03

26S proteasome non-ATPase regulatory subunit 14

PSMD14

2.80E+01

1.85E-03

26S proteasome non-ATPase regulatory subunit 2

PSMD2

2.15E+00

4.38E-03

26S proteasome non-ATPase regulatory subunit 3

PSMD3

3.04E+01

1.48E-04

26S proteasome non-ATPase regulatory subunit 4

PSMD4

2.79E+01

1.70E-04

26S proteasome non-ATPase regulatory subunit 6

PSMD6

2.96E+01

9.65E-03

26S proteasome non-ATPase regulatory subunit 7

PSMD7

3.75E+00

1.13E-02

26S proteasome non-ATPase regulatory subunit 8

PSMD8

2.75E+01

1.56E-03

Poly(U)-binding-splicing factor PUF60

PUF60

2.75E+01

9.95E-04

Pyrroline-5-carboxylate reductase

PYCR1

2.55E+01

3.49E-03

RNA-binding protein 10

RBM10

3.30E+01

4.88E-04

RNA-binding protein 14

RBM14

2.94E+01

6.57E-03

RNA-binding protein 25

RBM25

2.75E+01

7.71E-03

RNA-binding protein 26

RBM26

2.63E+01

3.79E-02

RNA-binding protein 27

RBM27

2.70E+01

1.20E-02

RNA-binding protein 28

RBM28

2.63E+01

5.02E-03

RNA-binding motif protein, X chromosome

RBMX

3.01E+01

8.90E-03

RNA 3-terminal phosphate cyclase-like protein

RCL1

2.65E+01

1.64E-03

Reticulocalbin-2

RCN2

2.73E+01

2.67E-03

Replication factor C subunit 3

RFC3

2.62E+01

2.34E-02

Telomere-associated protein RIF1

RIF1

3.04E+01

9.16E-03

Serine/threonine-protein kinase RIO1

RIOK1

3.02E+01

3.05E-03

RING finger protein 219

RNF219

2.94E+01

2.50E-03

RNA-binding protein 39

RNPC2

2.86E+01

8.92E-03

60S ribosomal protein L10

RPL10

3.26E+01

7.84E-03

60S ribosomal protein L10a

RPL10A

3.22E+01

2.24E-02

60S ribosomal protein L11

RPL11

3.19E+01

1.04E-03

60S ribosomal protein L12

RPL12

3.18E+01

6.43E-03

60S ribosomal protein L13

RPL13

3.30E+01

4.30E-04

60S ribosomal protein L13a

RPL13A

3.17E+01

2.25E-03

60S ribosomal protein L14

RPL14

3.07E+01

7.88E-04

60S ribosomal protein L15

RPL15

5.67E+00

8.90E-03

60S ribosomal protein L17

RPL17

3.16E+01

4.69E-04

60S ribosomal protein L18

RPL18

3.28E+01

1.68E-03

60S ribosomal protein L18a

RPL18A

3.24E+01

2.10E-03

Ribosomal protein L19

RPL19

3.26E+01

4.36E-03

60S ribosomal protein L21

RPL21

3.11E+01

1.99E-03

60S ribosomal protein L22

RPL22

3.05E+01

1.47E-03

60S ribosomal protein L22-like 1

RPL22L1

2.70E+01

6.60E-03

60S ribosomal protein L23

RPL23

3.09E+01

4.70E-03

60S ribosomal protein L23a

RPL23A

3.24E+01

1.26E-03

60S ribosomal protein L24

RPL24

3.03E+01

1.24E-03

60S ribosomal protein L26

RPL26

3.24E+01

1.20E-03

60S ribosomal protein L27

RPL27

3.18E+01

3.06E-03

60S ribosomal protein L27a

RPL27A

3.06E+01

5.33E-04

60S ribosomal protein L28

RPL28

3.22E+01

6.23E-04

60S ribosomal protein L29

RPL29

3.19E+01

3.76E-04

60S ribosomal protein L3

RPL3

7.15E+00

6.72E-03

60S ribosomal protein L30

RPL30

3.04E+01

2.06E-03

60S ribosomal protein L31

RPL31

3.15E+01

3.12E-04

60S ribosomal protein L32

RPL32

3.18E+01

3.51E-04

60S ribosomal protein L34

RPL34

2.90E+01

4.73E-03

60S ribosomal protein L35

RPL35

3.13E+01

1.43E-02

60S ribosomal protein L35a

RPL35A

3.14E+01

2.01E-02

60S ribosomal protein L36

RPL36

3.02E+01

1.49E-02

60S ribosomal protein L36a

RPL36A

2.97E+01

5.51E-04

60S ribosomal protein L37a

RPL37A

3.07E+01

1.05E-04

60S ribosomal protein L38

RPL38

2.90E+01

3.49E-02

60S ribosomal protein L4

RPL4

3.36E+01

1.82E-03

60S ribosomal protein L5

RPL5

3.26E+01

6.62E-03

60S ribosomal protein L6

RPL6

6.39E+00

9.35E-03

60S ribosomal protein L7

RPL7

3.33E+01

2.21E-03

60S ribosomal protein L7a

RPL7A

8.22E+00

1.74E-03

60S ribosomal protein L8

RPL8

3.33E+01

9.73E-04

60S ribosomal protein L9

RPL9

3.06E+01

1.10E-04

60S acidic ribosomal protein P0

RPLP0

3.23E+01

2.18E-03

60S acidic ribosomal protein P2

RPLP2

2.87E+01

4.32E-03

40S ribosomal protein S10

RPS10

3.21E+01

1.86E-03

40S ribosomal protein S11

RPS11

3.24E+01

1.88E-03

40S ribosomal protein S12

RPS12

3.14E+01

4.05E-04

40S ribosomal protein S13

RPS13

3.22E+01

1.60E-03

40S ribosomal protein S14

RPS14

3.15E+01

4.92E-04

40S ribosomal protein S15

RPS15

3.15E+01

3.33E-02

40S ribosomal protein S15a

RPS15A

3.19E+01

1.70E-03

40S ribosomal protein S16

RPS16

3.24E+01

1.08E-03

40S ribosomal protein S17

RPS17

3.19E+01

1.78E-03

40S ribosomal protein S18

RPS18

8.03E+00

7.90E-09

40S ribosomal protein S19

RPS19

3.22E+01

1.65E-03

40S ribosomal protein S2

RPS2

3.28E+01

1.71E-03

40S ribosomal protein S20

RPS20

3.21E+01

4.89E-04

40S ribosomal protein S21

RPS21

2.88E+01

2.47E-03

40S ribosomal protein S23

RPS23

3.25E+01

1.31E-03

40S ribosomal protein S24

RPS24

3.00E+01

1.10E-04

40S ribosomal protein S25

RPS25

3.14E+01

5.19E-03

40S ribosomal protein S26

RPS26

3.08E+01

2.54E-02

40S ribosomal protein S27

RPS27

3.00E+01

3.65E-03

40S ribosomal protein S3

RPS3

3.28E+01

3.26E-03

40S ribosomal protein S3a

RPS3A

3.30E+01

4.75E-04

40S ribosomal protein S4, X isoform

RPS4X

6.65E+00

2.28E-03

40S ribosomal protein S6

RPS6

3.18E+01

2.28E-03

40S ribosomal protein S7

RPS7

3.28E+01

1.99E-02

40S ribosomal protein S8

RPS8

3.24E+01

3.63E-03

40S ribosomal protein S9

RPS9

3.31E+01

3.94E-03

40S ribosomal protein SA

RPSA

3.32E+01

1.29E-03

Ribosome-binding protein 1

RRBP1

2.84E+01

3.20E-02

RRP12-like protein

RRP12

2.58E+01

1.13E-02

Ribosomal L1 domain-containing protein 1

RSL1D1

2.69E+01

1.56E-02

U4/U6.U5 tri-snRNP-associated protein 1

SART1

2.91E+01

1.18E-04

Splicing factor, arginine/serine-rich 15

SCAF4

2.74E+01

1.68E-02

Protein SDA1 homolog

SDAD1

2.64E+01

1.69E-02

Plasminogen activator inhibitor 1 RNA-binding protein

SERBP1

3.28E+01

2.19E-02

Splicing factor 3B subunit 1

SF3B1

2.81E+01

8.87E-03

Splicing factor 3B subunit 3

SF3B3

2.72E+01

1.14E-02

Superkiller viralicidic activity 2-like 2

SKIV2L2

2.75E+01

8.05E-03

U5 small nuclear ribonucleoprotein 200 kDa helicase

SNRNP200

3.06E+01

5.98E-03

U5 small nuclear ribonucleoprotein 40 kDa protein

SNRNP40

2.72E+01

1.41E-02

Small nuclear ribonucleoprotein Sm D1

SNRPD1

3.02E+01

1.48E-03

Small nuclear ribonucleoprotein Sm D2

SNRPD2

2.92E+01

2.94E-04

Small nuclear ribonucleoprotein Sm D3

SNRPD3

2.95E+01

1.93E-02

Small nuclear ribonucleoprotein-associated proteins B and B

SNRPN

3.06E+01

4.62E-04

Spectrin alpha chain, non-erythrocytic 1

SPTAN1

3.41E+01

9.63E-04

Spectrin beta chain, non-erythrocytic 1

SPTBN1

3.41E+01

9.41E-05

SRSF protein kinase 1

SRPK1

2.94E+01

5.81E-03

SRSF protein kinase 2

SRPK2

2.60E+01

2.88E-02

Serine/arginine repetitive matrix protein 1

SRRM1

2.85E+01

1.46E-02

Serrate RNA effector molecule homolog

SRRT

2.57E+01

2.04E-03

Serine/arginine-rich splicing factor 1

SRSF1

2.74E+01

1.86E-04

Serine/arginine-rich splicing factor 2

SRSF2

2.69E+01

4.59E-02

Serine/arginine-rich splicing factor 3

SRSF3

2.87E+01

1.42E-03

Double-stranded RNA-binding protein Staufen homolog 1

STAU1

2.88E+01

1.18E-02

Serine/threonine-protein kinase 38

STK38

2.78E+01

2.59E-02

SUN domain-containing protein 2

SUN2

2.97E+01

6.35E-04

Heterogeneous nuclear ribonucleoprotein Q

SYNCRIP

2.82E+01

1.08E-02

Very-long-chain enoyl-CoA reductase

TECR

2.70E+01

4.59E-03

Testis-expressed sequence 10 protein

TEX10

2.64E+01

1.64E-03

THO complex subunit 2

THOC2

2.53E+01

1.37E-02

Tight junction protein ZO-2

TJP2

2.65E+01

6.69E-03

Transmembrane protein 33

TMEM33

2.74E+01

1.11E-02

Tropomodulin-3

TMOD3

2.63E+01

4.62E-03

TRMT1-like protein

TRMT1L

2.82E+01

9.34E-03

Tubulin beta-3 chain

TUBB3

2.57E+01

5.04E-04

Tubulin beta-4A chain

TUBB4A

2.61E+01

2.90E-02

Splicing factor U2AF 35 kDa subunit

U2AF1

2.90E+01

7.02E-03

Splicing factor U2AF 65 kDa subunit

U2AF2

2.98E+01

4.30E-03

U2 snRNP-associated SURP motif-containing protein

U2SURP

2.78E+01

1.78E-05

E3 ubiquitin-protein ligase UBR5

UBR5

2.78E+01

2.75E-02

U4/U6.U5 tri-snRNP-associated protein 2

USP39

2.88E+01

2.14E-02

Transitional endoplasmic reticulum ATPase

VCP

2.80E+01

7.61E-05

Vimentin

VIM

1.35E+00

2.08E-02

Methylosome protein 50

WDR77

3.30E+01

2.27E-02

Exportin-T

XPOT

2.64E+01

7.27E-03

Nuclease-sensitive element-binding protein 1

YBX1

3.07E+01

3.00E-03

YTH domain-containing protein 1

YTHDC1

2.78E+01

8.82E-03

YTH domain-containing family protein 2

YTHDF2

1.60E+00

3.42E-02

Zinc finger CCCH domain-containing protein 18

ZC3H18

2.79E+01

1.14E-02

Zinc finger CCCH-type antiviral protein 1

ZC3HAV1

2.79E+01

1.27E-02

Zinc finger protein 622

ZNF622

2.75E+01

1.14E-02

  1. Log2 ratio and p-values were calculated using measured protein intensities, i.e. eXtracted Ion Current (XIC) of all isotopic clusters associated with the identified amino acid sequence. Log2 ratio was calculated from the intensity sum of samples/ controls. p-values are the result of a two-sided t-test, samples vs. control. In cases where intensities had been measured in 2 (out of 3) replicates, the third intensity value was added through imputation. If no intensity could be measured in all 3 replicates, the intensities were set from 0 to 1 in order to still be able to calculate a ratio (same applies to cases where only 1 intensity could be measured)