Fig. 5: 2-AP can attenuate BLM-induced pulmonary fibrosis and death in mice by inhibiting the EMT. | Cell Death Discovery

Fig. 5: 2-AP can attenuate BLM-induced pulmonary fibrosis and death in mice by inhibiting the EMT.

From: 2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis

Fig. 5

a Hematoxylin-eosin (HE) and Masson’s trichrome staining of lung specimens from mice that had been treated with BLM (2.5 mg/kg) for 21 days. b Survival of mice treated with BLM (2.5 mg/kg) and 2-AP (2 mg/kg), as indicated (n = 20 per group). c The levels of TGF-β1 in BALF were determined by ELISA. **P < 0.01 for BLM + 2-AP vs BLM. d The mRNA levels of E-cadherin and fibronectin were determined in lung tissue specimens. e The mRNA levels of Twist1 and Snail1 in mouse lung tissues were assessed. f The mRNA levels of Slug and vimentin were determined in lung specimens. *P < 0.05; *P < 0.01

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