Fig. 4: Integrated Circos plot of genes showing coordinately inversed DNA methylation and gene expression.

The outermost circle displays the human chromosomes. The inner six circles (four NOA and three OA samples displayed from outside to inside) represent the genome-wide distribution of differentially methylated probes. The innermost circles (four NOA and three OA samples displayed from outside to inside) represent the globally differentially expressed genes. The red indicates hypermethylation or overexpression, and blue indicates hypomethylation or under-expression