Fig. 3: High glucose shifts extrinsic apoptosis to RIP1-dependent cell death.
From: Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis
a Enhanced U937 cell death in response to the apoptotic stimulus, TNF-α/CHX, in high glucose conditions is prevented by the RIP1 inhibitor, nec-1s. b TNF/CHX-induced cell death of U937 cells depends on RIP1 across a range glucose concentrations between 20 and 50 mM. c Death of Jurkat T cells induced by FasL/CHX is enhanced in high glucose conditions in a RIP1-dependent manner. d Death of U937 cells by the intrinsic apoptotic stimulus, staurosporine/CHX, is prevented by pan-caspase inhibition with zVAD at 10 mM and 50 mM glucose. Inhibition of RIP1 with nec-1s has no effect on cell death at either glucose concentration. Two-way ANOVA, **p < 0.01, ***p < 0.001
