Fig. 7: High glucose shifts extrinsic apoptosis to necroptosis in primary human T cells.
From: Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis
a Levels of TNF-induced death of primary human T cells increase in high glucose (12.5 mM, 25 mM) relative to normal glucose (5 mM). Primary T cell death is prevented by the pan-caspase inhibitor, zVAD, at 5 mM but not at 12.5 or 25 mM glucose. b Enhanced death of primary T cells in hyperglycemic conditions (12.5 mM, 25 mM) is prevented by inhibition of RIP1 with nec-1s. Two-way ANOVA, ***p < 0.001
