Fig. 2: NVP-BEZ235 inhibited downstream targets of mTOR pathway. | Cell Death Discovery

Fig. 2: NVP-BEZ235 inhibited downstream targets of mTOR pathway.

From: NVP-BEZ235, a dual PI3K-mTOR inhibitor, suppresses the growth of FaDu hypopharyngeal squamous cell carcinoma and has a synergistic effect with Cisplatin

Fig. 2

FaDu HSCC cells were cultured in six-well plates and treated with 30 nM NVP-BEZ235 for 30 min (30 m), 1 h (1h), 2 h (2h), 1 day (1d), 2 days (2d), and 3 days (3d). Protein extracts of cells were analyzed by Western blotting with antibodies against p-mTOR, mTOR, phospho-p70S6K (p-p70S6K), p70S6K, phospho-4E-BP1 (p-4E-BP1), 4E-PB1, and β-actin

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