Fig. 4: Histological evidence for the myelin-protective effect and presence of EMSC in the CNS of treated monkeys. | Cell Death Discovery

Fig. 4: Histological evidence for the myelin-protective effect and presence of EMSC in the CNS of treated monkeys.

From: Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model

Fig. 4

a LFB & Eosin staining of spinal cord of C4-C7. EMSCsp treatment reduced the demyelination in the white matter of spinal cord in EAE monkeys. b Tracking of EMSC in the brain of EAE-induced monkey C5, C6, and C7 after the third i.t. injection with EMSCsp via immunostaining for human neural cell marker Stem121, GFP, myelin marker MBP. Scale bars, 20 μm. c Immunostaining showed Ki67+ cells in lesioned region of C5 brain. Scale bar, 20 μm

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