Fig. 6: Molecular docking of YL064 with STAT3.
From: YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
a, b Predicted conformation of YL064 in the pocket of STAT3 SH2 domain (a). The molecular surface of STAT3 SH2 domain is shown in white, the phosphotyrosine peptide are colored yellow. YL064 and pTyr705 are shown in pink and yellow sticks, respectively. b Residues of STAT3 are shown in cyan sticks and labeled with residue names. The dashed lines in black represent hydrogen bonds. c U266 cells were treated with DMSO or YL064 (20 μM) for 24 h, the dimerization of STAT3 was examined in non-denaturating gel
