Table 1 Pharmacokinetic analysis for single dose and repeated dose of 188Re-liposome treatment on HNSCC tumor-bearing mice

From: PEGylated liposome-encapsulated rhenium-188 radiopharmaceutical inhibits proliferation and epithelial–mesenchymal transition of human head and neck cancer cells in vivo with repeated therapy

Parameter

Unit

Single (188Re-BMEDA)

Single (188Re-liposome)

Repeated (188Re-liposome)

C max

%ID/mL

43.51 ± 10.16

55.37 ± 7.04

54.99 ± 8.48

Cl

mL/h

1.09 ± 0.20

0.31 ± 0.12

0.17 ± 0.04*

AUC(0→∞)

h ·[%ID/mL]

74.71 ± 10.46

348.75 ± 119.54

585.72 ± 141.29*

MRT

h

5.38 ± 0.50

11.55 ± 1.39

16.52 ± 1.72**

  1. For PK analysis in this table, data represent means ± SD, *p < 0.05, **p < 0.01
  2. Cmax : Larger maximal concentration, %ID : percentage injected dose, Cl: clearance, AUC(0→∞) : area under curve, MRT(0→∞): mean residence time [*Please change MRT(0->∞) to MRT]
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