Fig. 8: Proposed model for the study. | Cell Death Discovery

Fig. 8: Proposed model for the study.

From: Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity

Fig. 8

Exposure to the pesticide rotenone stimulates Eiger production in the brain milieu of w1118 flies which further induces the increased expression of the NADase Ect4 or dSarm from dopaminergic neurons. This, in turn, triggers the rapid loss of these neurons ultimately leading to severe motor deficits and loss of survival. Rotenone-induced neurotoxicity can be partially reversed in the presence of the anti-inflammatory molecule resveratrol which blocks the inflammatory response and subsequent Ect4 induction leading to improved motor functions

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