Fig. 5: OAGS changes in CD1 mice exposed to ETU since the conception. | Cell Death Discovery

Fig. 5: OAGS changes in CD1 mice exposed to ETU since the conception.

From: Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions

Fig. 5

A ETU effects on ovarian reserve were determined by qRT-PCR of established ovarian marker Amh, Gdf9, Bmp15, in mice exposed from the GD0 to PND180 (Fig S1, Supplementary information). B ETU-induced ovarian dysfunction was assessed by testing the OAGS across all doses of ETU by qRT-PCR. C miRNAs included into the OAGS were tested by qRT-PCR in all groups. D, E Mir143/Mir145 and cognate targets expression levels were determined by qRT-PCR. Data are reported as the ratio between mRNA/miRNA content in exposed and control groups normalized to β-actin/Rnu6 and, are mean ± s.d. with five animals per group. Significant differences are indicated with *P < 0.05; ** P < 0.01

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