Fig. 4: QSOX1-S inhibits integrinβ1/FAK and EGFR/Raf/ERK signaling pathways and its glycosylation at Asn-130 is necessary for this effect.

Integrinβ1/FAK pathway-related molecules (a) and EGFR/Raf/ERK pathway-related molecules (b) in MHCC97-H cells with QSOX1-S overexpression and Hep3B cells with QSOX1-S knockdown were analyzed by western blotting. Likewise, western blot analyses of integrinβ1/FAK pathway-related molecules (c) and EGFR/Raf/ERK pathway-related molecules (d) in MHCC97-H cells with mQSOX1-S overexpression are shown