Fig. 6: LC3 KD induces pyroptosis. | Cell Death Discovery

Fig. 6: LC3 KD induces pyroptosis.

From: Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction

Fig. 6

a LC3 KD did not change TREM-1 and Sirt6 expression. b LC3 KD directly provoked Casp1 maturation in ECs regardless of whether TREM-1 or Sirt6 was intact. c LC3 KD directly induced pyroptotic ECs formation regardless of whether TREM-1 or Sirt6 was intact. Scale bar: 50 μm. d Quantitation of pyroptotic cells using flow cytometry. N = 3, *p < 0.05 versus control group; #p < 0.05 versus ox-LDL group; **p < 0.05 versus Sirt6 KI group; ##p < 0.05 versus ox-LDL + TREM-1 KD group

Back to article page