Fig. 4: Effect of AVN-C on drug-induced hearing loss due to kanamycin and furosemide (K + F). | Cell Death Discovery

Fig. 4: Effect of AVN-C on drug-induced hearing loss due to kanamycin and furosemide (K + F).

From: Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress

Fig. 4

a Experimental timeline. AVN-C was injected intraperitoneally, 30 min prior to kanamycin injection. b After 1 month (M), the click auditory brainstem response (ABR) shows that K + F increased the threshold up to 78.75 ± 12.5 dB SPL. AVN-C prevented the threshold shift. Note that the low frequency 8 kHz threshold was also highly elevated by the K + F treatment, while AVN-C rescued it to almost normal. n = 3 per each group, *P < 0.05, **P < 0.01, ***P < 0.001

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