Fig. 2: Ddit3 deletion did not alter D2-associated endophenotypes. | Cell Death Discovery

Fig. 2: Ddit3 deletion did not alter D2-associated endophenotypes.

From: DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice

Fig. 2

a Semi-thin plastic sections of D2.Ddit3+/+ and D2.Ddit3−/− ONHs and retinas. Ddit3 deficiency did not cause gross morphological abnormalities of the ONH (left) or retina (right) in D2 mice (n = 6 per genotype). b D2.Ddit3+/+ and D2.Ddit3−/− IOPs taken at 5 M (n ≥ 76), 7.5 M (n ≥ 72), 9 M (n ≥ 60), 10.5 M (n ≥ 56), and 12 M (n ≥ 66). There was no difference in IOP between D2.Ddit3+/+ and D2.Ddit3−/− eyes at any time point (P > 0.05 for all comparisons, two-way ANOVA, Sidak post hoc). Note, for both genotypes, 9 M, 10.5 M, and 12 M IOPs were significantly elevated compared to the 5 M timepoint (P < 0.001 for all comparisons, two-way ANOVA, Sidak post hoc). The black line represents the median, and the upper and lower bounds represent the 90th and 10th percentiles, respectively. The red line represents the mean, and the top and bottom points of the red diamond represent the 95% confidence interval. Scale bar, 100 μm

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