Fig. 5: Total number of spontaneous “EEG seizure” events and EEG δ and θ power from WT and ALG13KO mice following diazepam treatment (2 and 0.25 mg/kg).
From: ALG13 participates in epileptogenesis via regulation of GABAA receptors in mouse models
a “EEG seizure” events were detected in ALG13KO mice implanted with cortical electrodes. Numbers in the first column indicate animal identifiers. Subsequent columns indicate the day during the recording period. Each individual box is color coded according to the legend. Each of the numbers in these boxes indicates the total number of events per day (n = 6 per group). Example of an event, defined as a high amplitude (>3 times baseline) rhythmic discharge, frequency (>5 Hz), and lasting longer than 5 s. Average number of spontaneous “EEG seizure” events from WT and ALG13KO mice following diazepam treatment (***P < 0.001, treatment of 2-mg/kg diazepam: WT compared with ALG13KO, one-way ANOVA test, n = 6; ***P < 0.001, treatment of 0.25-mg/kg diazepam: WT compared with ALG13KO, one-way ANOVA test, n = 6) bar, 1 mV, 1 s. b Comparison of baseline average δ and θ power between wild-type and ALG13KO mice and after treatment with 2 and 0.25-mg/kg diazepam (***P < 0.001, baseline: WT compared with ALG13KO, n = 6; **p < 0.01, WT: baseline compared with diazepam (2 mg/kg), n = 6; p > 0.05, baseline compared with diazepam (0.25 mg/kg), n = 6; ***P < 0.001, ALG13KO: baseline compared with diazepam (2 mg/kg), n = 6; ***P < 0.001, baseline compared with diazepam (0.25 mg/kg), n = 6. One-way ANOVA with a post hoc Bonferroni tests was performed.
