Fig. 2: Identification of 14-3-3ε isoform as a CCA-associated 14-3-3 family member, attenuating the efficiency of CDDP in CCA cells. | Cell Death Discovery

Fig. 2: Identification of 14-3-3ε isoform as a CCA-associated 14-3-3 family member, attenuating the efficiency of CDDP in CCA cells.

From: Arsenic trioxide enhances the chemotherapeutic efficiency of cisplatin in cholangiocarcinoma cells via inhibiting the 14-3-3ε-mediated survival mechanism

Fig. 2

a Expression levels of 14-3-3 family in tumor tissues/para-cancerous tissues (left) or in early stage/progression of tumor (right) based on the UCSC Xena database (https://xena.ucsc.edu). b Prognostic significance of 14-3-3 family based on the UCSC Xena database. c Western blot (top) and quantitative analysis (bottom) of the expressions of 14-3-3ε in HIBEC, HuCCT1, and RBE cells. d HuCCT1 cells were transfected by NC- or 14–3-3ε-siRNA, while RBE cells were transfected by vector or 14-3-3ε-plasmid. After then, they were treated by different concentrations of CDDP for 24 h. The cell viability was determined in triplicate, and the IC50s were calculated. Note: KD knockdown, OE overexpression. **p < 0.01 vs. HiBEC or MOCK group.

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