Fig. 3: Identification of PI-3K/Akt as an important phosphorylated signal pathway regulated by 14-3-3ε in CCA cells. | Cell Death Discovery

Fig. 3: Identification of PI-3K/Akt as an important phosphorylated signal pathway regulated by 14-3-3ε in CCA cells.

From: Arsenic trioxide enhances the chemotherapeutic efficiency of cisplatin in cholangiocarcinoma cells via inhibiting the 14-3-3ε-mediated survival mechanism

Fig. 3

a and b GO biological process and KEGG pathway analyses of the 50 most frequently altered neighbor factors around 14-3-3ε from STRING database, the size of the dot represents the number of genes enriched in the item. c HuCCT1 cells were transfected by NC- or 14–3-3ε-siRNA, while RBE cells were transfected by vector or 14-3-3ε-plasmid. Western blot (left) and quantitative analysis (right) of the expressions of p-PI-3K/p85 subunit and p-Akt. **p < 0.01 vs. MOCK group.

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