Fig. 3: A scheme that depicts the potential mechanism of how mutp53 affects the expression of Her2.
From: Attenuation of p53 mutant as an approach for treatment Her2-positive cancer
Mutp53 can influence transcription level of Her2, and as a result stabilize Her2. Mutp53 physically interacts with and enhances the transcriptional activity of HSF1, which is the main transcriptional regulator of Hsp90. Hsp90 stabilizes Her2 and mutp53 itself. Moreover, Her2 inhibitor lapatinib inhibits the ternary Her2–HSF1–mutp53 interaction, which leads to the destabilization of the mutp53 protein in cancer cells.
