Fig. 2: The CB1 receptor antagonist AM251 reversed the ACEA-induced effects on mitochondrial fission and the expression of fission-associated proteins. | Cell Death Discovery

Fig. 2: The CB1 receptor antagonist AM251 reversed the ACEA-induced effects on mitochondrial fission and the expression of fission-associated proteins.

From: Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway

Fig. 2

A Representative images of neuronal dendrites expressing Mito-DsRed, a mitochondrial marker. B Statistical results of the images in (A). C Western blot results showing the ACEA-induced effects on Drp1, Fis1, and Mff expressions. D AM251 reversed the ACEA-induced downregulation of Drp1 expression in OGD/R-induced HT22 cells. E AM251 reversed the ACEA-induced downregulation of Fis1 expression. F AM251 reversed the ACEA-induced downregulation of Mff expression. Bar = 1 µm; *p < 0.05; NS no significance.

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