Fig. 3: PTTG3P promotes tumor growth and metastasis of PDAC cells in vivo. | Cell Death Discovery

Fig. 3: PTTG3P promotes tumor growth and metastasis of PDAC cells in vivo.

From: A novel lncRNA PTTG3P/miR-132/212-3p/FoxM1 feedback loop facilitates tumorigenesis and metastasis of pancreatic cancer

Fig. 3

PTTG3P-overexpressing plasmid or shRNA treated PANC-1 or AsPC-1 cells were injected subcutaneously in the anterior armpit of nude mice (1 × 106 cells per mouse, five mice per group). a Gross tumor (a), tumor volume (b) and tumor weight (c) from indicated groups were shown. The formula to calculate the tumor volume is ab2/2, a represents the longest diameter of the tumor, and b represents the diameter perpendicular to the longest. d The expression level of Ki67 was examined by IHC analysis. Scale bars, 50 μm. e Representative images of HE-stained sections of metastatic nodules in the liver of nude mice (tumor areas are outlined with dashed lines; T tumor). Scale bars, 100 μm. f Mean and standard deviation of numbers of liver metastases were calculated. *P < 0.05.

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