Fig. 5: Glucose-independent induction of ROS produces a shift from apoptosis to necroptosis. | Cell Death Discovery

Fig. 5: Glucose-independent induction of ROS produces a shift from apoptosis to necroptosis.

From: Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis

Fig. 5

U937 cells were grown in 10 mM glucose and treated with TNF-α/CHX in the presence or absence of superoxide dismutase inhibitor, diethyldithiocarbamate (DDC), for 24 h followed by WST-1 viability assay. A Cell death in the absence of DDC is prevented by the pan-caspase inhibitor, zVAD-fmk. Cell death in the presence of DDC is unaffected by zVAD-fmk. B Cell death in the presence of DDC is prevented by RIP1 inhibitor, necrostatin-1s (nec-1s). All results are from three independent experiments. Graphed values represent mean ± standard deviation. Two-way ANOVA, ***p < 0.001.

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