Fig. 2: m6A induced the upregulation of LINC00958 in BC cells.
From: m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
A MeRIP-Seq analysis revealed a notable m6A modification site at the LINC00958 location. B RT-PCR indicated upregulated METTL3 mRNA expression in the BC cell line (MCF-7). C METTL3 knockdown (sh-METTL3) was transfected into MCF-7 cells to silence METTL3 expression. D M6A analysis (colorimetric method) presented m6A modification enrichment in sh-METTL3 or sh-NC transfection. E MeRIP-qPCR illustrated the m6A-modified LINC00958 level after METTL3 silencing or control. F RNA stability analysis demonstrated the LINC00958 level in MCF-7 cells transfected with METTL3 silencing. **p < 0.01 was considered as significant.
