Fig. 4: High expression of NF90-Ser382 phosphorylation indicates poor prognosis of HCC.
From: NF90 stabilizes cyclin E1 mRNA through phosphorylation of NF90-Ser382 by CDK2
a NF90 mRNA expression levels were analyzed in 107 paired HCC specimens by qRT-PCR and normalized to β2-microglobulin (β2 MG). A two-fold change threshold was set for identifying significant changes in gene expression. T, tissue; N, non-tumor tissues. b The phosphorylation level of NF90-Ser382 in 8 paired HCC specimens. β-actin served as the loading control. T, tissue; N, non-tumor tissues. c Comparison of NF90-S382 phosphorylation levels in tumor tissues and non-tumor tissues. Intensity of the NF90-S382 phosphorylation level was calculated by ImageScope software. Scatter plots, mean (n = 76); bar, s.d. p value was shown in the picture. d Survival rate is correlated with NF90-S382 phosphorylation level. Low level of NF90-S382 phosphorylation was associated with longer survival.
