Fig. 3: TFEB function and mechanism of TFEB activation.
From: Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases
a TFEB regulates several biological processes, such as autophagy, lysosomal biogenesis, lysosomal exocytosis, lipophagy, mitophagy, etc. b Under nutrient-rich conditions, TFEB is predominantly found in its inactive state that is characterised by mTORC1 and ERK2-mediated phosphorylation. When cells experience stress or disease, TFEB is activated by dephosphorylation.
