Fig. 1: Early pregnancy miR-125b status was associated with risk of PE. | Cell Death Discovery

Fig. 1: Early pregnancy miR-125b status was associated with risk of PE.

From: Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia

Fig. 1

a Heatmap of top plasma miRNA candidates upregulated in the plasma between PE (n = 6) and control pregnancies (n = 6). Red indicates upregulation and green indicates downregulation of miRNA level. 16 miRNAs were identified as deregulated in the plasma of patients who went on to develop PE by microarray. Scatter plots (b) and volcano plot (c) for preeclampsia and control comparisons using average miRNAs expression data were presented. d miR-125b expression in PE and control plasma. Blood samples between 12 + 0 and 13 + 6 weeks of gestation were collected when pregnant women went for their initial hospital appointment. miR-125b was significantly elevated in patients who finally developed PE (n = 15) compared to control (Ctrl, n = 29). **p < 0.01. e Comparison of plasma miR-125b before and 48 h after delivery. Blood samples were collected when preeclampsia patients went hospital due to disease onset and after the delivery for 1 week. All data are represented as mean ± SEM, asterisks indicate significance, with p < 0.01 by Student’s t test.

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