Fig. 5: miR-125b inhibited trophoblast invasion via KCNA1 mediation. | Cell Death Discovery

Fig. 5: miR-125b inhibited trophoblast invasion via KCNA1 mediation.

From: Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia

Fig. 5

The invasiveness of HTR8/SVneo cells transfected with miR-125b, miR-125b inhibitor, and KCNA1 siRNA were determined using Transwell insert invasion assay, as presented the typical field in a and relative invasion index in b. N = 3 performed in triplicates and results are presented as mean ± SEM. Statistical comparison between miR-125b mimics (or inhibitor) and the negative control was performed using Student t test, with p < 0.05 considered as significant. *p < 0.05, **p < 0.01. c Typical microscope fields of Transwell insert invasion assays to examine cell invasion in HTR8/SVneo cells transfected with either KCNA1 overexpressing pcDNA 4 vector (pcKCNA1) or pcDNA 4 vector (pDNA4). miR-125b mimic or negative control miRs was co-transfected. d Relative invasion index based on 3 independent experiments performed in triplicates and results are presented as mean ± SEM. with p < 0.05 considered as significant. *p < 0.05, **p < 0.01.

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