Fig. 1: Molecular mechanism of FBXO45 in controlling cellular functions via targeting multiple substrates. | Cell Death Discovery

Fig. 1: Molecular mechanism of FBXO45 in controlling cellular functions via targeting multiple substrates.

From: FBXO45 is a potential therapeutic target for cancer therapy

Fig. 1

FBXO45 targets numerous substrates for ubiquitination and degradation, including FBXW7, p73, Par-4 and ZEB1/2. Hey1, miR-27a and m6A regulate the expression of FBXO45. FBXO45 has a critical role in cell death, apoptosis, EMT and drug resistance.

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