Table 1 FBXO45 targets substrates for degradation in human diseases.
From: FBXO45 is a potential therapeutic target for cancer therapy
Substrates | Cell lines | Functions | Reference |
|---|---|---|---|
ERα | HeLa, MCF-7 | Involves in tissue-selective oestrogen complex-mediated endometriosis therapy | |
Munc13-1 | 293T, hippocampal neuron cells, COS. | Controls synaptic activity, neuropathic allodynia | |
NMNAT2 | 293T | Regulates axon degeneration | |
p73 | BT-20, 293T, HeLa | Reduction of cell death | |
Par-4 | HeLa, 293T | Reduction of cell apoptosis, promotes cell survival | |
FBXW7 | U2OS, HeLa | Governs cell fate decision, chemotherapy resistance | |
ZEB1/2, Snail1/2, Twist1 | 293T, HeLa, U2OS, MCF-7, MDA-MB-231, PANC-1 | Regulates EMT |
