Fig. 2: Kinesin-1 drives muscle regeneration in mice. | Cell Death Discovery

Fig. 2: Kinesin-1 drives muscle regeneration in mice.

From: Dexamethasone accelerates muscle regeneration by modulating kinesin-1-mediated focal adhesion signals

Fig. 2

a Experimental scheme for the skeletal muscle regeneration experiments. The tibialis anterior (TA) muscles in the left hind legs of mice were injured using 1.2% BaCl2 via intramuscular (i.m.) injection on day 0. Next, the mice were randomly grouped and administered with DMSO, Dex (0.1 mg/kg) or Dex (0.1 mg/kg) + RBL (30 mg/kg) everyday via intraperitoneal (i.p.) injection. To assess whether Dex is able to accelerate skeletal muscle regeneration via kinesin-1, mouse TA muscle samples were collected at various time points. b Representative histology images of mouse TA muscles of the various study groups. The regenerating myofibers with peripheral nuclei marked with blue arrows. Scale bar, 50 μm. c The number of regenerative muscle fibers, calculated as the number of fibers with accumulation of centrally located nuclei, as shown in b. Data are mean ± s.e.m (n = 5 independent fields). *p < 0.05; **p < 0.01; ***p < 0.001; NS no significance.

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