Fig. 6: JAC1 modulates HER2 ubiquitination and inhibits tumor growth in vivo.
From: JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
a The curve of tumor growth of BT474 xenografted breast cancer after JAC1 treatment. b, c The ratio of tumor weight/body weight in each group (b), tumor inhibition rate by JAC1 (c). d The expressions of cell proliferation biomarkers and mechanism biomarkers in isolated representative tumor tissues of each group; all the biomarkers were determined by western blot. e A schematic overview of how JAC1 degrades HER2 in breast cancer cells. *P < 0.05; **P < 0.01; ***P < 0.001. N.S. no significant differences.
