Fig. 7: ZFAS1 knockdown is associated with decreased tumor growth in vivo compared to not-target siRNA. | Cell Death Discovery

Fig. 7: ZFAS1 knockdown is associated with decreased tumor growth in vivo compared to not-target siRNA.

From: Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma

Fig. 7

a ZFAS1 knockdown was associated with decreased tumor volume in a mouse xenograft model compared to non-target siRNA, with significant differenes observed from day 3 after mass was first identified in each mouse. The differences were most pronounced from day 7 up until day 14 when the experiment was terminated (N = 4 replicates) (*p = 0.006, **p < 0.001, ***p = 0.024). b Illustration of the signaling cascade demonstrated by these results.

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