Fig. 7: Relationship of NR3C1 and IL-6 expression to COVID-19 status and clinical severity. | Cell Death Discovery

Fig. 7: Relationship of NR3C1 and IL-6 expression to COVID-19 status and clinical severity.

From: Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patients

Fig. 7

A Correlation between IL-6 and NR3C1 expression in the macrophage population found to most robustly co-express these two genes (“Macrophages 4”). Each dot represents the percentage of cells from this cluster (i.e., cell population) in which IL-6 and NR3C1 were detected, and dots are colored by COVID-19 status and clinical severity. Values shown are the Pearson correlation coefficient (“R”) and corresponding p-value (“p”). B Comparison of NR3C1 expression in the “Macrophage 4” cell population from patients with mild versus severe COVID-19. C Coexpression of NR3C1 with the two subunits of the GM-CSF receptor (CSF2RA and CSF2RB) in the bronchoalveolar lavage fluid of COVID-19 patients (n = 9; 3 mild, 6 severe). Top coexpressing populations, all of which are macrophages, are shown.

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