Fig. 2: Caspase-1 inhibition downregulates overload-induced pyroptosis. | Cell Death Discovery

Fig. 2: Caspase-1 inhibition downregulates overload-induced pyroptosis.

From: NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

Fig. 2

A Immunoblots showing levels of cleaved caspase-1 (A1, A2), IL-1β (A1, A3), and GSDMD-N (A1, A4) in the indicated groups. B Percentage of TUNEL-positive cells in the indicated groups. C Immunoblots showing levels of cleaved caspase-1 (C1, C2), IL-1β (C1, C3), and GSDMD-N (C1, C4) in the suitably treated cardiomyocytes. D Percentage of PI-positive cells in the indicated groups. Results are mean ± SEM, n = 6. *P < 0.01 compared to control, #P < 0.01 compared to TAC group or Ang-II group. YVAD (AC-YVAD-CMK, caspase-1 inhibitor).

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