Fig. 6: Overexpression of NLRP3 reversed irisin-mediated antipyroptosis and anticardiac hypertrophy effects. | Cell Death Discovery

Fig. 6: Overexpression of NLRP3 reversed irisin-mediated antipyroptosis and anticardiac hypertrophy effects.

From: NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

Fig. 6

A Immunoblots showing protein levels of NLRP3 and ASC (A1, A2), cleaved caspase-1, and GSDMD-N (A1, A3) in the suitably treated cardiomyocytes. B Percentage of PI-positive cells in the suitably treated cardiomyocytes. C Measurement of the cell surface area of cardiomyocytes in the indicated groups. D mRNA expression of cardiac hypertrophy markers BNP and β-MHC in the suitably treated cardiomyocytes. Results are presented as the mean ± SEM, n = 6. ∗P < 0.01 compared to control, #P < 0.01 compared to Ang-II group, &P < 0.01 versus Ang-II + Irisin group.

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