Fig. 4: Crosstalk between nerves and immune cells. | Cell Death Discovery

Fig. 4: Crosstalk between nerves and immune cells.

From: Role of the nervous system in cancers: a review

Fig. 4

ACh is synthesized in the T cells by enzyme choline acetyltransferase. Adrenergic innervation stimulates production of the T-cell-derived ACh, which is involved in regulating the tumor immunity and tumor biology behavior. Endoneural macrophages also regulate tumor metastasis through CXCL10. CXCL10 recruits the myeloid cells and suppresses T cells via VISTA and PD-L1.

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