Fig. 2: PHGDH expression is a poor prognostic marker for colon cancer, Ewing’s sarcoma and breast tumours. | Cell Death Discovery

Fig. 2: PHGDH expression is a poor prognostic marker for colon cancer, Ewing’s sarcoma and breast tumours.

From: Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?

Fig. 2

A Analysis of PHGDH expression levels in normal colon (32 patients-Marra), colon cancer (232 and 290 patients-Sieber), Ewing’s Sarcoma (37 patients-Francesconi) and breast tumours (204 and 123 patients-Bos). (**P:0.0025; ***P:0.0001) B Kaplan-Meier survival curve based on high and low PHGDH expression levels in colon cancer, Ewing’s sarcoma and breast tumours derived from SieverSmith, Savola and Booser cohort with 355, 117 and 508 patients, respectively. Tumours with high PHGDH expression showed decreased survival. Data were acquired from the R2:GenomicsAnalysisandVisualizationPlatform and significance is calculated with a one-way ANOVA between groups.

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