Fig. 5: TAK1 inhibition exerts a beneficial effect on histological structure and neurological recovery in SCI mice. | Cell Death Discovery

Fig. 5: TAK1 inhibition exerts a beneficial effect on histological structure and neurological recovery in SCI mice.

From: Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury

Fig. 5

A Trinary immunofluorescence shows the distribution of NF200 (green), GFAP (red), and IBA1 (pink) in the lesion site of the spinal cord at 28 dpi; a, Scale bar = 200 μm; b, Scale bar = 50 μm. B Quantification of the IBA1-positive area in the spinal cord at 28 days post-SCI. ∗∗∗P < 0.001 versus Sham group, ## P < 0.01versus SCI group; n = 6 in each group. C Quantification of the GFAP-positive area in the spinal cord at 28 days post-SCI. D Representative HE staining photos of the spinal cord in Sham, SCI, SCI + ZO group at 28 dpi; Bar scale = 200 μm. E Quantification of tissue integrity in the spinal cord. F The BMS score post SCI, # P < 0.05 versus SCI group.

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