Fig. 2: The effect of the overexpression or knockdown of miR-5000-3p and treatment with or without OXA on cell survival of HCT116 and LoVo or OR-HCT116 and OR-LoVo cells in vitro. | Cell Death Discovery

Fig. 2: The effect of the overexpression or knockdown of miR-5000-3p and treatment with or without OXA on cell survival of HCT116 and LoVo or OR-HCT116 and OR-LoVo cells in vitro.

From: miR-5000-3p confers oxaliplatin resistance by targeting ubiquitin-specific peptidase 49 in colorectal cancer

Fig. 2

A miR-5000-3p expression after transfections with miR-5000-3p inhibitors or mimics in two OR-CRC cell lines or two CRC cell lines. B miR-5000-3p expression in HCT116 and LoVo or OR-HCT116 and OR-LoVo cells transfected with a miR-5000-3p mimics (40 nM), inhibitor (40 nM), or NC miRNA (40 nM) (mimics negative control (NC) or inhibitor NC) or treatment with OXA (45 µ M). miR-5000-3p fold increase which was calculated by the ratio miR-5000-3p/U6, being U6 snRNA constitutively expressed. C Relative cell survival fold changed of HCT116 and LoVo cells or OR-HCT116 and OR-LoVo cells determined by the MTT assay. *p < 0.05, **p < 0.01, and ***p < 0.001; #p < 0.05, ##p < 0.01, and ###p < 0.001.

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