Fig. 1: The circRNAs profile of the exosomes from CAFs in hypoxia stress. | Cell Death Discovery

Fig. 1: The circRNAs profile of the exosomes from CAFs in hypoxia stress.

From: Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

Fig. 1

A The representative pictures of exosomes from CAFs in hypoxia and normoxia. B The exosome markers were identified by western blotting. C The heat map showed the most significant circRNAs in exosomes from CAFs in the presence of hypoxia and normoxia. CircRNA expression profiles were performed by circRNA array. The map showed the differentially expressed circRNAs over two-folds change. The red color indicated high expression level, and the green color indicated a low expression level. D The top ten different circRNAs in the hypoxic exosomes from normoxic exosomes. E circRNA distribution in hypoxia CAFs and normoxia CAFs. F The resources of circRNAs. G The scatter plot was used to assess the variation in circRNA expression between H-exo and N-exo. The values of x- and y-axes in the scatter plot were the normalized signal values of the samples (log2 scaled). The green lines were fold-change lines. H Volcano plot showed the differential circRNAs in exosomes of hypoxic and normoxic CAFs. Left red indicated the down-regulated circRNAs. Right red indicated the upregulated circRNAs. I KEGG analysis of circRNAs in H-exo vs. N-exo. J GO analysis of circRNAs in hypoxia H-exo vs. N-exo. K The top ten upregulated circRNAs in the exosomes from hypoxic CAFs. *p < 0.05, **p < 0.01.

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