Fig. 7: A model for the regulation of autophagy mediated by acetyltransferase/deacetylase in B. mori and mammals. | Cell Death Discovery

Fig. 7: A model for the regulation of autophagy mediated by acetyltransferase/deacetylase in B. mori and mammals.

From: P300/HDAC1 regulates the acetylation/deacetylation and autophagic activities of LC3/Atg8–PE ubiquitin-like system

Fig. 7

Components of the LC3/Atg8–PE ubiquitin-like system are acetylated by acetyltransferase, such as BmP300, and then translocated from the cytoplasm to the nucleus under nutrient-rich conditions. Simultaneously, high MTOR activity phosphorylates the histone deacetylases BmHDAC1/HsHDAC1, resulting in their nuclear localization. 20E, cholesterol derivatives, and starvation, which inhibit MTOR signaling, leads to the dephosphorylation of BmHDAC1/HsHDAC1, and facilitates the deacetylation of Atg proteins from LC3/Atg8–PE ubiquitin-like system, subsequently promoting their nucleo-cytoplasmic translocation and autophagy occurrence in both B. mori and mammals.

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