Fig. 2: Potential mechanisms underlying GRP75 caused cisplatin-resistance. | Cell Death Discovery

Fig. 2: Potential mechanisms underlying GRP75 caused cisplatin-resistance.

From: Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming

Fig. 2

A and B GO-Biological process and KEGG-pathway analyses of DEGs from the GSE122130 dataset. C and D GO-Biological process and KEGG-pathway analysis of DEGs from the GSE14209 dataset. E Network-Analyst was used to analyze the PPI network of GRP75 and its interactors according to the KEGG database. F A hypothetic scheme showed that GRP75 might promote survival and growth of GC which leading to cisplatin-resistance via anti-oxidation/apoptosis and metabolic reprogramming, but the mechanism was unknown.

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