Fig. 3: Effects of GRP75 on anti-oxidation and anti-apoptosis. | Cell Death Discovery

Fig. 3: Effects of GRP75 on anti-oxidation and anti-apoptosis.

From: Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming

Fig. 3

A The intracellular ROS levels of SGC7901CR or SGC7901 cells were determined in triplicate. B–E SGC7901CR cells were transfected by scrambled or GRP75 siRNA, while SGC7901 cells were transfected by scrambled or GRP75 plasmids. After then, they were treated with 5 or 2.5 μM of cisplatin for 24 h. B MMP of GC cells was measured and calculated. C Western blot analysis of the levels of NRF2; and qPCR analysis in triplicate of the expressions of HO-1 and NQO-1. D and E The intracellular ROS levels and apoptosis rates (early apoptosis plus late apoptosis) were determined in triplicate.

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