Fig. 2: Hypoxia promots miR-155-5p selectively imported into exosomes. | Cell Death Discovery

Fig. 2: Hypoxia promots miR-155-5p selectively imported into exosomes.

From: Hypoxic TAM-derived exosomal miR-155-5p promotes RCC progression through HuR-dependent IGF1R/AKT/PI3K pathway

Fig. 2

A The variation in miRNA expression between RCC and normal tissues from GSE116251 was compared. B Hierarchical cluster heat map of differentially expressed miRNAs in RCC and corresponding normal tissues from the GSE116251 data set. Red in the heat map denotes upregulation; Green denotes downregulation. C The top 7 upregulated miRNAs are listed. D The top 7 most abundant miRNAs were measured in exosomes derived from un-activated macrophages (control), TAM and hypoxic TAM (H-TAM). E Relative miRNA levels of RCC cells co-cultured with exosome released from TAM or hypoxic TAM. To block the exosome uptake into cells, EIPA (10 μM) was added in the media during co-culture. F Data set from GSE11625 showed the enrichment of miR-155-5p in the enrolled RCC individuals. G The Pearson correlation analysis of the transcription level of miR-155-5p and CD163 in TCGA database (P < 0.001). **P < 0.01, ***P < 0.001.

Back to article page