Table 2 Prognostic value of early phase circulating GSTA2 protein in HCC recipients after liver transplantation.
1. Prediction of HCC recurrence | ||||||
---|---|---|---|---|---|---|
 | ROC analysis | Logistics Regression | ||||
Factors | Sensitivity (%) | Specificity (%) | AUC (95% CI) | P value | HR | P value |
Early phase plasma GSTA2 protein (high vs. low) | 45.8 | 85.4 | 0.70 (0.57–0.83) | 0.003** | 9.034 | 0.002** |
Milan Criteria (beyond vs. within) | 83.3 | 67.1 | 0.75 (0.65–0.86) | 0.000*** | 1.046 | 0.966 |
UCSF criteria (beyond vs. within) | 75.0 | 82.9 | 0.79 (0.68–0.90) | 0.000*** | 7.532 | 0.035* |
Tumor size (≥3 cm vs. <3 cm) | 82.6 | 52.4 | 0.68 (0.56–0.79) | 0.010** | 3.148 | 0.141 |
Vascular permeation (yes vs. no) | 59.1 | 79.3 | 0.69 (0.56–0.82) | 0.006** | 3.773 | 0.062 |
Pre-OT AFP level (≥400 ng/ml vs. <400 ng/ml) | 33.3 | 88.9 | 0.61 (0.47–0.75) | 0.097 | N/A |  |
Graft weight to recipient ESLV (<60% vs. >60%) | 75.0 | 37.8 | 0.56 (0.44–0.69) | 0.342 | N/A |  |
Type of transplant (LDLT vs. DDLT) | 79.2 | 24.4 | 0.52 (0.39–0.65) | 0.792 | N/A |  |
Tumor number (>3 vs. <3) | 34.8 | 89.0 | 0.62 (0.48–0.76) | 0.082 | N/A |  |
Differentiation (poor vs. well) | 23.8 | 94.9 | 0.59 (0.45–0.74) | 0.190 | N/A |  |
2. Prediction of disease-free survival | ||||
---|---|---|---|---|
 | Disease-free survival | |||
Factors | Univariate regression | Multivariate regression | ||
 | HR (95% CI) | P value | HR (95% CI) | P value |
Plasma GSTA2 protein (high vs. low) | 2.24 (1.13–4.45) | 0.021* | 1.75 (0.81–3.75) | 0.154 |
Sex (male vs. female) | 1.04 (0.43–2.51) | 0.928 |  |  |
Age (≤55 yr vs. <55 yr) | 1.06 (0.54–2.08) | 0.860 |  |  |
Serum AFP (>400 ng/ml vs. ≤400 ng/ml) | 2.89 (1.37–6.07) | 0.005** | 1.73 (0.70–4.26) | 0.234 |
Tumor size (>3 cm vs. ≤3 cm) | 1.96 (0.95–4.02) | 0.068 |  |  |
Tumor number (>3 vs. ≤3) | 2.00 (0.09–4.44) | 0.088 |  |  |
Vascular permeation (yes vs. no) | 2.36 (1.19–4.68) | 0.014* | 1.246 (0.54–2.87) | 0.606 |
Differentiation (poor vs. well) | 3.08 (1.26–7.54) | 0.013* | 1.90 (0.73–4.95) | 0.191 |
UCSF criteria (beyond vs. within) | 4.22 (2.13–8.37) | 0.000*** | 2.30 (1.00–5.31) | 0.050 |
Milan Criteria (beyond vs. within) | 3.09 (1.53–5.25) | 0.002** | N/A |  |
Type of LT (DDLT vs. LDLT) | 1.30 (0.61–2.78) | 0.500 | N/A |  |
Graft size (>60% vs. ≤60%) | 0.75 (0.38–1.47) | 0.402 | N/A |  |