Fig. 2: Effect of erlotinib on LPS-induced parthanatos. | Cell Death Discovery

Fig. 2: Effect of erlotinib on LPS-induced parthanatos.

From: Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression

Fig. 2

Macrophages collected from peritoneal lavage at 24 h after pretreated with erlotinib or 3-AB with LPS treatment. a, c Immunoblotted for PARP-1 activation, PAR formation, and GAPDH. b, d Mensuration of PARP-1 (b) and PAR (d) expressions. e Immunoblot analysis of AIF and Lamin B amount in nuclei. f Mensuration of AIF expression in nuclei. g Fluorescence images depicting AIF translocation (up panel; scale bar, 100 μm). Error bars represent SD (n = 3). *P < 0.05 as compared with NC; †P < 0.05 as compared with LPS group.

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