Fig. 6: The role of TLR4 in parthanatos and the MyD88 and/or the PI3K signaling pathway in parthanatos. | Cell Death Discovery

Fig. 6: The role of TLR4 in parthanatos and the MyD88 and/or the PI3K signaling pathway in parthanatos.

From: Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression

Fig. 6

One of the reasons that LPS-induced ROS production leads to parthanatos. Erlotinib could inhibit the cells surface TLR4 expression and alleviated the parthanatos in response to LPS. This may be through the MyD88 and/or the PI3K signaling pathway. Besides, erlotinib inhibits the generation of ROS, which in turns inhibits parthanatos.

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