Fig. 7: Enrichment plots from gene set enrichment analysis (GSEA).

A GSEA results showing differential enrichment of genes in GO with ferroptosis-related lncRNAs (5 GO items, namely, positive regulation of activation of innate immune response, innate immune response activating signal transduction, interleukin 1 mediated signaling pathway, positive regulation of innate immune response, and regulation of apoptotic signaling pathway), showed significantly differential enrichment in the high expression phenotype. Five GO items, namely, CD8-positive alpha beta T cell activation, mast cell-mediated immunity, regulation of leukocyte-mediated immunity, regulation of lymphocyte-mediated immunity, and T cell-mediated immunity, showed significantly differential enrichment in the low expression phenotype. B GSEA results showing differential enrichment of genes in KEGG with ferroptosis-related lncRNA expression. (5 KEGG items namely, positive regulation of pancreatic cancer, cell cycle, p53 signaling pathway, pathogenic Escherichia coli infection, and small cell lung cancer were significantly differential enrichment in high expression phenotype; 5 KEGG items namely, ferroptosis -related lncRNA, FC epsilon RI signaling pathway, autoimmune thyroid disease, and allograft rejection and graft versus host disease showed significantly differential enrichment in the ferroptosis-related lncRNA low-expression phenotype based on the normalized enrichment score (NES), nominal p value (NOM P value), and FDR value).